Saturday, September 22, 2007

Aging? Take a pill, says biopharm Co.

Over seven decades, researchers have shown that calorie restriction, or at least a 30-40 percent cut in the normal calorie intake, extends healthy lifespan in multiple species, including mice and rats.

Replicating similar reasons to humans, researchers of a new study offer ways to mimic like effects of low calorie diet in humans, using a pill – perhaps a pill that fights multiple diseases and also activates the body's own anti-aging defense mechanism.

Sirtuins, a recently-discovered class of enzymes that promote the body's natural defense against disease, there are seven human sirtuins (SIRT1-7), classed according to their sequence of amino acids.

A biopharmaceutical company, headquartered in Cambridge, Massachusetts, Sirtris Pharmaceuticals is already working on the drug that imitates certain beneficial health effects of calorie restriction, without requiring a change in eating habits, by activation of sirtuins. The experimental pill - SRT501 is already in the Phase 2a trials in patients suffering from Type-2 diabetes.

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